Physical Analysis of Pharmaceutical Polymorphic Forms and their Phase Transitions
About the book..
This reference provides several examples of physical analysis of pharmaceutical polymorphic forms (polymorphs, hydrates, solvates and their polymorphs) on 125 pages with over 100 figures. It includes systematic coverage of the most significant technique used in characterization of polymorphic forms - the Powder X-ray Diffraction (XRPD), which is the golden standard of polymorph characterization. It builds up on the information delivered in “Solid State Characterization of Pharmaceuticals”, the text book issued in 2006. This book signifies potential difficulties associated with application of the PXRD technique to pharmaceutical compounds and demonstrates potential and frequent errors associated with this technique on several pharmaceutical compounds. Finally, the text offers hardware and experimental remedies for interpretation of otherwise ambiguous results.
About the author…
Dr. Marek Zakrzewski is a founder of and a consultant to Analytics Sp. z O. O. (www.analytics-pharm.com) and an Adjunct Associate Professor at School of Pharmacy of University of Connecticut.
He received his M.Sc, (1981) in applied solid state physics from Technical University of Lodz, Poland and Ph.D. (1990) in Solid State Chemistry from Dalhousie University, Halifax, Canada specializing in molecular crystals and clathrates. Next he continued his interest in clatharate hydrates at National Research Council of Canada. He has authored several publications, presentations and patents and has worked for several years in the Pharmaceutical Sciences area holding managerial positions in the USA and Holland for international companies like Procter & Gamble Pharmaceuticals, Rhone-Poulenc Rorer Aventis, Philips Analytical X-ray and Purdue Pharma. He has designed, co-authored, edited and published one of the most unique books on the subject of characterization of pharmaceutical solid state occurring substances; “Solid State Characterization of Pharmaceuticals”. He has founded a series of conferences called “International Workshops on Physical Characterization of Pharmaceutical Solid” and served as a member of the scientific organizing committee of eight of them. He has taught several courses to pharmaceutical industry in the USA, Germany and India.